30 Seconds Summary
Ribosome Biogenesis Influences Whether High Volumes Cause More Growth

  • The study utilized a within-subject unilateral design where subjects trained different legs with varying weekly set volumes (6 vs. 18 sets), observing more muscle growth and strength in the higher volume leg.
  • Participants who experienced significant growth or strength developed a higher ribosome content, linking the volume of resistance training to ribosomal biogenesis.
  • The study involved 34 untrained but healthy adults, assessing strength and muscle changes via biopsies and MRI, over a 12-week training period.
  • Only approximately 30% to 40% of subjects showed notably better results with higher training volumes, identifying total RNA as a strong indicator of how well subjects responded to more intensive training.
  • The research explored both single- and multiple-set training protocols, leading to varied strength and hypertrophy outcomes among individuals.
  • Higher resistance training volumes are generally associated with increased muscle growth and strength, but the response levels vary widely among individuals.
  • Key findings suggest that understanding ribosomal responses early in training could potentially personalize and optimize training volumes for different individuals.
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The hypertrophic response to resistance training is highly variable between individuals, potentially due to the magnitude of the myofibrillar protein synthetic response, increase in ribosome content, and increase in satellite cell number. This is the first paper to examine these variables in relatio…

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