30 Seconds Summary
Research Spotlight: Caffeine and strength: Do your genes matter?

  • Recent research has focused on how the CYP1A2 and ADORA2A genes affect responses to caffeine, particularly in relation to metabolism and receptor binding.
  • Early studies suggested individuals with the 'fast' AA genotype of CYP1A2 and the CT or CC genotype of ADORA2A might react differently to caffeine's performance-enhancing effects.
  • Two new studies by Grgic et al explored these genetic influences on caffeine's impact on strength and power, not just endurance.
  • The first study showed that caffeine improved various metrics of strength and power in men, regardless of their CYP1A2 genotype.
  • In the second study, even participants with the ADORA2A 'non-responder' CT or CC genotype experienced enhanced exercise performance with caffeine.
  • These findings suggest that regardless of genetic makeup concerning these two genes, individuals may still receive performance benefits from caffeine.
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