30 Seconds Summary
Research Spotlight: Exogenous ketones do not improve endurance performance

  • Glycogen is crucial for fueling endurance sports but depletes quickly in long or intense activities.
  • The study tested whether ketone esters could preserve glycogen and enhance performance in trained cyclists and triathletes.
  • Participants took 65g of ketone esters or a placebo in three doses during a testing session featuring a 3-hour cycling stint and time trials.
  • Despite intake of ketone esters, there was significant muscle glycogen breakdown, which was similar to the placebo group.
  • Ketone esters did not improve overall cycling performance, time trial power output, or time to exhaustion in sprinting.
  • Some participants reported a higher perceived exertion midway through the cycling session when consuming ketone esters.
  • Overall, exogenous ketones do not appear to spare glycogen stores or improve endurance performance in highly trained athletes.
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